Eleven Cases of Vancomycin-Induced Drug Fever in Children and Literature Review

Peng Jing; Xu Hua; Li Xinlin; Li Qiaoling

doi:10. 13407/ j. cnki. jpp. 1672-108X. 2023. 07. 004

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Eleven Cases of Vancomycin-Induced Drug Fever in Children and Literature Review

更新时间：2023-08-23

- Eleven Cases of Vancomycin-Induced Drug Fever in Children and Literature Review
- Vol. 29, Issue 7, Pages: 14-17(2023)
- 作者机构：
  
  华中科技大学同济医学院附属武汉儿童医院,武汉,430016
- 作者简介：
- 基金信息：
- DOI：10. 13407/ j. cnki. jpp. 1672-108X. 2023. 07. 004
  CLC：
- Published：2023，
  
  Published Online：10 July 2023，
扫描看全文
Peng Jing, Xu Hua, Li Xinlin, et al. Eleven Cases of Vancomycin-Induced Drug Fever in Children and Literature Review. [J]. 29(7):14-17(2023)
DOI：

Peng Jing, Xu Hua, Li Xinlin, et al. Eleven Cases of Vancomycin-Induced Drug Fever in Children and Literature Review. [J]. 29(7):14-17(2023) DOI： 10. 13407/ j. cnki. jpp. 1672-108X. 2023. 07. 004.

摘要

目的:探讨儿童应用万古霉素引起药物热的临床特点

为临床安全合理用药提供参考。方法:收集华中科技大学同济医学院附属武汉儿童医院 2017 年 7 月至 2021 年 6 月应用万古霉素引起药物热的住院患儿

并对国内儿童使用万古霉素引起药物热的病例报道进行文献复习

总结用药剂量、药物热发生时间、不良反应处理及转归情况。结果:共收集万古霉素引起药物热的患儿 11 例

其中我院 4 例

文献报道 7 例。药物热发热时间 5. 0(2. 0~10. 0)d

最高体温 39. 1(38. 3~40. 0)℃

停药后退热时间1. 9(1. 0~3. 0)d

可伴随其他器官和全身不良反应

发热期间实验室检查结果未见感染指标明显升高

停药后预后良好。结论:万古霉素引起儿童药物热与感染性疾病的发热较难鉴别

应结合药物使用时间、实验室检查结果及患儿发热特点加以判断

及时停用可疑药物

避免出现严重不良反应。

Abstract

Objective: To investigate the clinical characteristics of vancomycin-induced drug fever in children

so as to provide reference for the safety of clinical drug use. Methods: Children with vancomycin-induced drug fever admitted into Wuhan Children’ s Hospital

Tongji Medical College

Huazhong University of Science & Technology from Jul. 2017 to Jun. 2021 were collected. Literature review was conducted on the case reports of vancomycin-induced drug fever in children in China

and the drug dosage

duration

adverse drug reaction symptoms and outcomes were summarized. Results: A total of 11 children with vancomycin-induced drug fever were enrolled

including 4 cases in our hospital and 7 cases reported in literature. The duration of drug fever was 5. 0 (from 2. 0 to 10. 0) d

the maximum body temperature was 39. 1 (from 38. 3 to 40. 0) ℃

and the duration of fever remission was 1. 9 (from 1. 0 to 3. 0) d

which could be accompanied by other organs and systemic adverse drug reactions. No significant increase of infection indicators was found in laboratory tests during fever

and the prognosis was good after drug withdrawal. Conclusion: Vancomycin-induced drug fever in children is difficult to distinguish from fever of infectious diseases

so it should be judged by the time of drug use

laboratory test results and fever characteristics of the children

and the suspected drug should be stopped in time to avoid severe adverse drug reactions.

关键词

万古霉素药物热儿童

Keywords

ancomycinrug feverchildren

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